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The CAPRISA Clinical Trials: HIV Treatment and Prevention

The CAPRISA Clinical Trials: HIV Treatment and Prevention

Edition:1

Author(s) :Quarraisha Abdool Karim, Salim S. Abdool Karim, Cheryl Baxter (eds.)

Year :2017

ISBN :9783319475172, 9783319475189

Pages :VI, 243[23

Language :English

Extension :pdf

Size :5 Mb (4832024)

Summary :

Since its inception 14 years ago, CAPRISA has conducted numerous clinical studies that have influenced international TB-HIV treatment guidelines as well as HIV prevention through innovations in the microbicide and vaccine fields. This book provides a historical account of how each of CAPRISA’s high impact studies was created, developed, implemented, analysed and communicated. In doing so, the reader is taken on a journey that provides glimpses into the genesis of research ideas and how this ultimately leads to a range of HIV prevention and treatment studies that have impacted the global response to the HIV and TB epidemics. Comprised of 5 sections, the book details the following: HIV epidemic in South Africa and the establishment of a research centre to undertake clinical, epidemiological and laboratory research on HIV.CAPRISA’s clinical trials on HIV and HSV-2 prevention. These studies investigated the impact of tenofovir gel as topical antiretroviral pre-exposure prophylaxis (PrEP), implementation of topical PrEP through family planning clinics, conditional cash incentives for HIV prevention, HIV vaccines, and passive immunisation with broadly neutralising antibodies. CAPRISA’s research on the treatment of HIV and TB co-infection. A review of the major scientific findings from the CAPRISA studies on acute infection and genital mucosal immunology. Essential support activities for the conduct of clinical trials, including research laboratories and pharmacies, as well as establishing effective communication and sustainable structures for community engagement to maintain effective and respectful partnerships with participating communities. The book concludes with a chapter about the challenges facing future HIV prevention and treatment trials. The CAPRISA Clinical Trials: HIV Treatment and Prevention is a resource for undergraduate and postgraduate students, health care providers, doctors, decision-makers and researchers who are seeking guidance and insights on clinical trials – their creation, conduct and impact. Table of contents : Front Matter....Pages i-vi Front Matter....Pages 1-1 Studies Linked to the Evolving HIV Epidemic in South Africa: Informing the CAPRISA Scientific Agenda....Pages 3-13 CAPRISA: Establishing a Research Centre to Undertake HIV Clinical Trials....Pages 15-25 Overview of Clinical Trials....Pages 27-38 Front Matter....Pages 39-39 Antiretrovirals for HIV Prevention: The CAPRISA 004 Tenofovir Gel Trial....Pages 41-56 Rolling Out of Tenofovir Gel in Family Planning Clinics: The CAPRISA 008 Implementation Trial....Pages 57-75 The Impact of Conditional Cash Transfers in Reducing HIV in Adolescent Girls and Boys (RHIVA): The CAPRISA 007 Matched Pair, Cluster Randomised Controlled Trial....Pages 77-89 HIV Vaccine and Passive Immunity Trials....Pages 91-104 Front Matter....Pages 105-105 CAPRISA 003: Timing of Antiretroviral Initiation in HIV-TB Co-infected Patients—The SAPiT Trial....Pages 107-120 Scaling up TB-HIV Integration in Public Health Clinics: Translating Research Findings into Practice....Pages 121-134 Front Matter....Pages 135-135 From Bench to Bedside: Lessons from HIV Natural History Cohort Studies....Pages 137-152 Advancing Understanding of HIV Infection in Women Through Mucosal Immunology Studies....Pages 153-166 Front Matter....Pages 167-167 Good Practices in the Conduct of Clinical Trials: Good Community, Pharmacy and Laboratory Practices....Pages 169-189 Ethical and Legal Considerations for Realising Post-trial Access of Novel Experimental Interventions: Lessons from the CAPRISA 004 Trial....Pages 191-200 Grants Management....Pages 201-207 Taking Science to the People: CAPRISA Communication and Media Strategies for Announcing Outcomes of Pivotal Study Findings....Pages 209-230 What Does the Future Hold for CAPRISA?....Pages 231-233 Back Matter....Pages 235-243
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Book category:2017

Book views:264

Eidt day:2017-04-11




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