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Peptidomimetics Protocols

Peptidomimetics Protocols

Edition:1 edition

Author(s) :Wieslaw M. Kazmierski

Year :1998

ISBN :9780896035171, 0896035174

Pages :538\538

Language :English

Extension :PDF

Size :28 MB (29305082 byte

Summary :

A state-of-the-art collection of detailed synthetic procedures that lead to a variety of scaffolds, turn mimetics, peptide-bound replacements, and enzyme inhibitors. Topics range from unusual syntheses of amino acids to the use of a variety of linear and heterocyclic scaffolds in place of the peptide backbone. Important chemical procedures and methods include the transient protection of charged peptides as neutral prodrugs for improved blood-brain penetration and the replacement of peptide bonds with heterocyclic rings, olefins and fluoroolefins, and ketomethylenes. Synthetic protocols towards the transition-state mimics and reactive "warheads," applicable in enzyme inhibitors, are also disclosed.
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Book category:1998

Book views:1375

Eidt day:2017-08-16




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