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Peptidomimetics Protocols

Peptidomimetics Protocols

版本:1 edition

作者 :Wieslaw M. Kazmierski

年份 :1998

编号 :9780896035171, 0896035174

总页数 :538\538

语言 :English

文件类型 :PDF

大小 :28 MB (29305082 byte

简介 :

A state-of-the-art collection of detailed synthetic procedures that lead to a variety of scaffolds, turn mimetics, peptide-bound replacements, and enzyme inhibitors. Topics range from unusual syntheses of amino acids to the use of a variety of linear and heterocyclic scaffolds in place of the peptide backbone. Important chemical procedures and methods include the transient protection of charged peptides as neutral prodrugs for improved blood-brain penetration and the replacement of peptide bonds with heterocyclic rings, olefins and fluoroolefins, and ketomethylenes. Synthetic protocols towards the transition-state mimics and reactive "warheads," applicable in enzyme inhibitors, are also disclosed.
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书籍分类:1998

阅读次数:1378

编辑日期:2017-08-16


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